Science & Research » Products in Development
Genmab is building a deep pipeline of fully human antibody products to
maximize its opportunities for success. We have ten products in clinical
trials and have the financial flexibility needed to move our
products forward. Genmab has chosen to focus on products to treat various
cancers, infectious diseases, and autoimmune and inflammatory conditions.
Human antibodies are expected to be particularly useful in treating these
conditions as they should lend themselves to long-term therapy without the
risk of rejection by the body's immune system. Furthermore, Genmab is
evaluating a large number of interesting disease targets, including several
concerning infectious diseases, for future product development.
| Title | Indications | Development Status | Our Rights |
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| Zanolimumab (HuMax-CD4) | | Cutaneous T-cell lymphoma (CTCL) | Phase III | Worldwide | | Non-cutaneous T-cell lymphoma (NCTCL) | Phase II (completed) | Worldwide | | NCTCL w/CHOP | Phase II | Worldwide |
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| Ofatumumab (HuMax-CD20) | | Chronic lymphocytic leukemia (CLL) | Phase III | Worldwide in collaboration with GlaxoSmithKline (GSK) | | Non-Hodgkin’s lymphoma (NHL) | Phase III | Worldwide in collaboration with GSK | | Rheumatoid Arthritis (RA) - methotrexate ref. | Phase III | Worldwide in collaboration with GSK | | RA - TNF-alpha ref. | Phase III | Worldwide in collaboration with GSK | | CLL front line w/FC | Phase II | Worldwide in collaboration with GSK | | NHL front line w/CHOP | Phase II | Worldwide in collaboration with GSK | | Diffuse large B-cell lymphoma (DLBCL) | Phase II | Worldwide in collaboration with GSK | | Relapsing remitting multiple sclerosis (RRMS) | Phase II | Worldwide in collaboration with GSK | | RA - subcutaneous | Phase I/II | Worldwide in collaboration with GSK |
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| Zalutumumab (HuMax-EGFr) | | Head and neck cancer | Phase III | Worldwide | | Head and neck cancer front line w/radiotherapy | Phase III | Worldwide | | Non small cell lung cancer w/chemo-radiation | Phase II | Worldwide | | Head and neck cancer front line w/chemo-radiation | Phase I/II | Worldwide | | Colorectal cancer w/iriniotecan | Phase I/II | Worldwide | | Head and neck cancer w/radiotherapy | Phase I/II | Worldwide |
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| R1507 | | Sarcoma | Phase II | Worldwide in collaboration with Roche |
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| HuMax-IL8 | | Palmoplantar pustulosis | Phase I/II (completed) | Worldwide |
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| HuMax-CD38 | | Multiple Myeloma | Phase I/II | Worldwide |
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| Roche 2 | | Undisclosed | Phase I | Worldwide in collaboration with Roche |
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| Roche 3 | | Undisclosed | Phase I | Worldwide in collaboration with Roche |
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| Roche 4 | | Asthma | Phase I | Worldwide in collaboration with Roche |
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| HuMax-HepC | | Hepatitis C | Pre-clinical | Worldwide |
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| HuMax-TAC | | Organ transplant rejection | Pre-clinical | Worldwide |
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| HuMax-CD32b | | Cancer | Pre-clinical | Worldwide |
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